The Peptide Observer

Peptide research, explained for people who are not scientists.

Word

Actin sequestration

Built from index records dated 2026-10-09 Compiled by an automated pipeline, checked by The Peptide Observer editorial desk How this site works

Cells build tiny internal scaffolding out of a protein called actin. Sequestering actin means holding the loose units so they cannot be built into that scaffolding.

Holding a building block so it cannot be used.

How the research records put it

Actin sequestration is the binding of monomeric actin so that it is unavailable for filament assembly. A 1991 Journal of Biological Chemistry paper reports that thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable, and a 1992 Molecular Biology of the Cell paper addresses the control of actin nucleotide exchange by thymosin beta 4 and profilin.[1, 2]

That paragraph is the reference wording, carried unchanged, with the record it came from. The plain sentence above it is this publication speaking, and it carries no citation because it adds nothing the reference wording does not hold.

Where this word turns up

2 entries in this index name this word in its records. 2 of them are described on this site.

It turns up on these group pages: Tissue repair peptides.

And in these quick answers: TB-500, Thymosin beta 4.

Where this comes from

The record the reference wording is taken from.

  1. Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable. J Biol Chem (1991). pmid:1999398
  2. The control of actin nucleotide exchange by thymosin beta 4 and profilin. A potential regulatory mechanism for actin polymerization in cells. Mol Biol Cell (1992). pmid:1330091