Quick answer
What is MOTS-c?
Built from index records dated 2026-10-09 to 2026-10-13 Compiled by an automated pipeline, checked by The Peptide Observer editorial desk How this site works
MOTS-c is a peptide, grouped on this site under Mitochondrial and longevity-associated peptides, and the 12 research records kept here are 8 from studies in rats or mice and 4 that do not state what kind of study it is.
The literature search returned 272 records. This site keeps 12 of them, which is 4.4 per cent of what came back.
What it is
This site puts it in the Mitochondrial and longevity-associated peptides group.
A mitochondrial-encoded peptide; the retrieved records report nuclear translocation and regulation of metabolic homeostasis rather than action at a named surface receptor.[1, 2]
Stated in the titles of the cited 2018 and 2015 Cell Metabolism papers.
What kind of records
The records kept here are animal and laboratory studies only.
That sentence is produced by counting, not by reading. What was counted: no interventional human trial record; 8 rodent and 0 in vitro records among 12.
What this does not settle
- What it does in a body. Counting records is not reading them, and nothing here has been read in full.
- Whether it causes harm. No adverse-effect row was taken from any source for this entry.
- How long it lasts. No pharmacokinetics source was retrieved for this entry.
- What the other 260 retrieved records say. They are not in this index.
The longer explanation
Where this comes from
The records cited above, in full.
- The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell metabolism (2018). pmid:29983246
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell metabolism (2015). pmid:25738459